个人履历
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深圳湾实验室转化医学中心，研究员
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Scripps研究所/Dale L. Boger课题组，博士后
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杨百翰大学/Steven L. Castle课题组，博士
研究领域
研究方向包括多肽与蛋白质工程、药物化学等。从事多肽、ADC（抗体药物偶联）、PDC（多肽药物偶联）、RDC（核素药物偶联）等药物的研发，围绕肿瘤、代谢与心血管疾病等领域，探索治疗新靶点、发现临床前候选物。
获奖情况
- 2016
Christine Bireley Oliver Fellowship, US
- 2016
Loren C. and Maurine F. Bryner Award, US
- 2015
Jerald S. Bradshaw Organic Chemistry Fellowship, US
- 2015
Graduate Research Fellowship, US
- 2013-2015
Simmons Center for Cancer Research Fellowship, US
发表文章
1. Singh, J.; Nelson, TJ; Mansfield, SA; Nickel,GA; Cai, Y.; Jones DD; Small JE; Ess DH; and Castle SL* “Microwave-and Thermally Promoted Iminyl Radical Cyclizations: A Versatile Method for the Synthesis of Functionalized Pyrrolines” J. Org. Chem. 2022, 87,16250-16262.
2. Lin, XL; Zhu, W.; Wang, YJ; Cai, Y.;Dong, XY; Yang, DY; Tan, FM; Ma, ZP; Li, LF; Gao, JL “Potential medical application of plasmin-based therapeutics” Sys Rev Pharm 2021, 12,3832-3849.
3. Singh J.; Nickel, G. A.; Cai, Y.;Jones, D. D.; Nelson, T. J.; Small, J. E.; and Castle, S. L.* “Synthesis of functionalized pyrrolines via microwave-promoted iminyl radical cyclizations” Org. Lett. 2021, 23, 3970
4. Cai, Y.; Ma, Z.; Jiang, J.;Lo, C.; Luo, S.; Jalan, A.; Cardon, J. M.; Ramos, A.; Moyá, D. A.; Joaquin, D.;and Castle, S. L.* “Convergent Total Synthesis of Yaku’ amide A” Angew. Chem. Int. Ed.,2021,60,5162-5167.
5. Zou,Z.; Wang, L.; Zhou, Z.; Sun, Q.; Liu, D.; Chen, Y.; Hu, H.; Cai, Y.;Lin, S.; Yu, Z.; Tan, B.; Guo, W.; Ling, Z.; Zou, X.; “Simultaneous incorporation of PTH(1-34) and nano-hydroxyapatite into Chitosan/AlginateHydrogels for efficient bone regeneration” Bioactive Materials, 2021,6, 1839-1851.
6. Moore, M. J.; Qu, S.; Tan, C.; Cai, Y.;Moji, Y.; Keith, D. J.; and Boger, D. L.; “Next-Generation Total Synthesis of Vancomycin”J. Am. Chem. Soc., 2020, 142, 16039-16050.
7. Jackman, M. M.; Cai, Y.; Castle, S. L.* “Recent Advances inIminyl Radical Cyclizations” Synthesis 2017, 49, 1785-1795.
8. Cai, Y.; Jalan, A.; Kubosumi, A.R.; Castle, S. L.* “Microwave-promoted tin-free iminyl radical cyclization with TEMPO trapping: A practical synthesis of 2-acylpyrroles” Org. Lett. 2015, 17, 488-491.
9. Ma, Z.; Jiang, J; Luo, S.; Cai,Y.; Cardon, J. M.; Kay, B. M.; Ess, D. H.; Castle, S. L. “Selective Access to E- and Z-ΔIle-Containing Peptidesvia a Stereospecific E2 Dehydration and an O→N Acyl Transfer” Org. Lett. 2014, 16, 4044–4047.
10. Liu, A.; Ma, R.; Song, C.;Yang, Z.; Yu, A.;* Cai, Y.; He, L.;* Zhao, Y.; Yu, B.; Song, Q. “Equimolar CO2 Capture by N-Substituted Amino Acid Salts and Subsequent Conversion” Angew. Chem. Int. Ed. 2012, 51, 11306
11. Yu, A.;* Wang, H.; Xue, X.; Cai, Y.; Wang, Y.; He, J. “Theoretical study on the thermodynamic hydricity of imidazole-based organic hydrides inacetonitrile” Chem. J. Chinese U. 2012,33, 276-281.
12. Cai, Y.; Wang, Y.;Wang, J.; Song, C.; Yu, A.* “Antioxidant activity studies using electron paramagnetic resonance methods” Prog.Chem. 2011, 23, 1959-1972.
13. Xue, X.; Yu, A.;* Cai, Y.; Cheng, J. “A computational reinvestigation of the formation of N-alkylpyrroles via intermolecular redox amination” Org. Lett. 2011, 13, 6054-6057.
14. Hou, Y.;* Long, G.;Sui, D.; Cai, Y.; Wan, X.; Yu, A.; Chen, Y.* “Different donor-acceptor structures of dithiafulvalene-fused semiconducting polymers with different band gaps” Chem. Commun. 2011,47, 10401-10403.