TIMELINE
- 2020-至今
深圳湾实验室转化医学中心 研究员
- 2013-2020
贝勒医学院 博士后/staff scientist
- 2011-2013
中科院上海生物化学和细胞生物学研究所 助理研究员
- 2004-2011
中科院上海生命科学研究院 博士
- 2000-2004
大连理工大学 学士
研究领域
以肝癌和前列腺癌为研究对象，从事肿瘤发生发展的分子机制和靶向治疗的基础应用转化研究。
代表论文
1. Wang L, Cheng CM, Qin J, XuM, Kao CY, Shi J, You E, Gong W, Rosa LP, Chase P, Scampavia L, Madoux F,Spicer T, Hodder P, Xu HE, Tsai SY*, Tsai MJ*. The use of small molecule inhibitors targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Science Advances. 2020 Apr 29;6:eaaz8031.
2. Wang L, Xu M, Kao CY, TsaiSY*, Tsai MJ*. Small molecule JQ1 promotes prostate cancer invasion via BET-independent inactivation of FOXA1. Journal of Clinical Investigation. 2020 Apr1;130(4):1782-1792.
3. Kao CY#, Xu M#, Wang L#,Lin SC, Lee HJ, Duraine L, Bellen HJ, Goldstein D, Tsai SY*, and Tsai MJ*. Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson’s disease through mitochondrial dysfunction. PLOS Genetics. 2020 Jun 24;16(6):e1008868 (#co-firstauthor). 2020 Jun 24.
4. Wang L, Feng J, Da L, Li Y, Li Z, Zhao M*. Adenovirus-mediated delivery of siRNA targeting TM4SF4 attenuated liver cancer cell growth in Vitro and in Vivo. ActaBiochim Biophys Sin. 2013 Mar;45(3):213-9.
5. Li Y#, Wang L#, Qiu J, Da L, Tiollais P, Li Zand Zhao M*. Human tetraspanin transmembrane 4 superfamily member 4 or intestinal and liver tetraspan membrane protein is overexpressed in hepatocellular carcinoma and accelerates tumor cell growth. Acta Biochim Biophys Sin 2012,44(3):224-232 (#co-firstauthor).