Timeline
- 2022-至今
深圳湾实验室转化医学中心 转化研究员
- 2020-2022
北京大学深圳研究生院 助理研究员
- 2017-2020
犹他大学 博士后
- 2012-2017
北京大学 博士
- 2008-2012
四川大学 学士
研究领域
研究方向包括多肽化学生物学、蛋白质工程、药物化学、有机化学。从事多肽与蛋白质药物研发，围绕代谢与心血管疾病、神经退行性疾病等领域，探索治疗新靶点、发现临床前候选物。
代表论文
1. Nan Zheng, Sean B. Christensen, Cheryl Dowell, Landa Purushottam, Jack J.Skalicky, J. Michael McIntosh,Danny Hung-Chieh Chou. Discovery of Methylene Thioacetal-Incorporated α-RgIA Analogues as Potent and Stable Antagonists of Human α9α10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain. J. Med. Chem. 2021, 64, 9513-9524.
2. Nan Zheng, Sean B. Christensen, Alan Blakely, Cheryl Dowell, Landa Purushottam, J. Michael McIntosh*, Danny Hung-Chieh Chou.Development of Conformationally Constrained α-RgIA Analogues as Stable Peptide Antagonists of Human α9α10 Nicotinic Acetylcholine Receptors. J. Med. Chem. 2020, 63, 8380-8387.
3. Nan Zheng, Prasoona Karra, Michael A. VandenBerg, Jin Hwan Kim, Matthew J.Webber, William L. Holland, Danny Hung-Chieh Chou. Synthesis and Characterization of an A6-A11 Methylene Thioacetal Human Insulin Analogue with Enhanced Stability. J. Med. Chem. 2019, 62, 11437-11443.
4. Nan Zheng, Lijie Zhang, Jianxian Gong, and Zhen Yang. Formal Total Synthesis of (±)-Lycojaponicumin C. Org. Lett. 2017, 19, 2921-2924.
5. Nai-Pin Lin,+ Nan Zheng,+ Landa Purushottam, Yi Wolf Zhang, DannyHung-Chieh Chou. Synthesis and Characterization of Phenylboronic Acid-modifiedInsulin with Glucose-dependent Solubility. Front Chem. 2022,10, 859133.